Depends on what you mean by 'better'. Let me tell you right now, I've heard lots of terrible orchestral pieces on the SNES, simply due to having a lot of bad/low quality samples stuffed into the SPC RAM, and hoping for the best. There's a reason many SNES games have simply really bad sounding strings (as in,
the sort played this way), cymbols, choirs, and sometimes guitars. To get decent sounding instruments out of those without obvious looping needs a long sample. Either the composer does a short but 'obvious' sounding sample, or a long but low quality sample.
This sort of conundrum isn't generally an issue with synth, but finding people that can get decent instruments out of it is. It's just a crying shame that more composers/sound drivers didn't support looped samples via the DAC.
The thought process shouldn't be "synth vs. sampled", the thought process should
really be "How do we get the best out of both worlds?".